Infiltration refers to the inadvertent administration of a non-vesicant medication or solution Amiodarone. -Supportive management.
CYP3A4 and P-gp inhibitors (e.g. amiodarone, aprepitant, azole Administer oxaliplatin (irritant with vesicant properties):. via IV infusion
Amiodarone is a vesicant that can cause progressive and severe tissue destruction. Drug Interactions: amiodarone digoxin = increased digoxin levels; amiodarone warfarin = increased warfarin effect; amiodarone beta blockers = increased effects of both drugs; amiodarone calcium channel blockers = increased effects of both drugs
Infiltration is the accidental leakage of non-vesicant solutions out of the vein into the surrounding tissue. Amiodarone Arginine
Amiodarone is a vesicant that can cause progressive and severe tissue destruction. Drug Interactions: amiodarone digoxin = increased digoxin levels; amiodarone warfarin = increased warfarin effect; amiodarone beta blockers = increased effects of both drugs; amiodarone calcium channel blockers = increased effects of both drugs
When vesicant drugs extravasated, they cause tissue damage. Amiodarone, Amphotericin. Caffeine, Gentamicin. Metronidazole, Pentamidine
Loperamide if required. Extravasation. Vincristine is vesicant (Group 5) Amiodarone: increased risk of pulmonary fibrosis – avoid if possible.
Amiodarone (Pacerone) is an antiarrhythmic which works by prolonging the vesicant properties (pH ~ 4). Sometimes I give a mg load in the OR
Leaking of vesicant drugs into surrounding tissue Can cause severe local E.g. of drugs – Chemotherapeutic drugs, amiodarone, amphotericin
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