Drugs that increase inr

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Actual: Medications that interact with warfarin by increasing the INR and chances of a catastrophic bleed, or by decreasing the INR and exposing patients to the risk
4.6 rating 2025-04-24
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A mild increase in the INR is not unexpected with prednisone, but warrants particular caution if the patient requires a second drug that also affects INR for example, trimethoprim

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Increasing the INR target or adding an antiplatelet drug should be considered if an embolic event occurs whilst the person is anticoagulated at the target INR.

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Increased INR and prothrombin time in patients receiving PPIs, including omeprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead

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In nearly half of a cohort of elderly patients, the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-

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Medications that interact with warfarin by increasing the INR and chances of a catastrophic bleed, or by decreasing the INR and exposing patients to the risk

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by X Zhang 2024 Cited by 3Conclusion: Azvudine, warfarin, and rivaroxaban might have previously unidentified drug interactions that increased the INR. Therefore, the INR

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Consider a one-time dose increase of 1 times daily maintenance dose If adjustment to maintenance dose needed, increase dose by 5-10% Repeat INR in 2 weeks INR 2.3 2.4 INR 2 3 Desired range Repeat INR within 8 weeks INR 2.5 3.5 INR 3.1 3.2 No dosage adjustment may be necessary if the last two INRs were in range

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Warfarin. Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including omeprazole, and warfarin concomitantly. Increases in INR

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INR 1.8 1.9 No dosage adjustment may be necessary if the last two INRs were in range Repeat INR within 8 weeks Consider a one-time dose increase of 1 times daily maintenance dose If adjustment to maintenance dose needed, increase dose by 5-10% Repeat INR in 2 weeks INR 2.3 2.4 INR 2 3 Desired range

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