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Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma Vigorex concentrations when coadministered with Vigorex (50 mg) to healthy volunteers. When a single 100 mg dose of Vigorex was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in

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Indications Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Vigorex to be effective, sexual stimulation is required. Vigorex is also indicated in pulmonary arterial hypertension. Description Vigorex is a selective, reversible inhibitor of cyclic guanosine monophosphate

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When a single 100 mg dose of Vigorex was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in Vigorex systemic exposure (AUC).

210% increase in Vigorex AUC. Vigorex had no effect on saquinavir In a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and Vigorex

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erection sufficient for satisfactory sexual performance. In order for Vigorex to be effective, sexual stimulation is required. drugs. Vigorex has

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