Fosphenytoin vs phenytoin

Fosphenytoin displaces phenytoin from protein binding sites. The volume of distribution of fosphenytoin increases with fosphenytoin sodium injection dose and rate, and ranges from 4.3 to 10.8 liters. Elimination. The conversion half-life of fosphenytoin to phenytoin is approximately 15 minutes. Metabolism

Phenytoin and fosphenytoin are the same active medication. For these reasons fosphenytoin is the preferred second line agent for treatment of

Fosphenytoin (Cerebyx) is a pro-drug of Phenytoin (Dilantin). Differences between fosphenytoin and phenytoin are primarily due to fosphenytoin being more water soluble. Fosphenytoin versus Phenytoin: Fosphenytoin less risk for cardiac-related adverse effects (propylene glycol not required for solubilization)

Dose equivalence and conversion for fosphenytoin sodium Doses are expressed as phenytoin sodium equivalent (PE); fosphenytoin sodium 1.5 mg ≡ phenytoin sodium

Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus. Fosphenytoin was developed in

by M Madhiyazhagan 2024Department comparing phenytoin versus fosphenytoin protocol over of seizure with phenytoin compared to the fosphenytoin arm (17.7% vs.

Fosphenytoin: 95 99%. Phenytoin: 88%. Fosphenytoin displaces phenytoin from binding sites. In the presence of fosphenytoin, the fraction of unbound phenytoin increases; 70% of phenytoin is bound during the period required for conversion of fosphenytoin to phenytoin (approximately 0.5 1 hour post-infusion). Special Populations

Fosphenytoin is a prodrug. It is converted rapidly (half-life15 minutes) to phenytoin. Fosphenytoin is less alkaline than phenytoin and can be

Fosphenytoin (Cerebyx) is a pro-drug of Phenytoin (Dilantin). Differences between fosphenytoin and phenytoin are primarily due to fosphenytoin being more water soluble. Fosphenytoin versus Phenytoin: Fosphenytoin less risk for cardiac-related adverse effects (propylene glycol not required for solubilization)