Myeloma criteria

International Myeloma Working Group Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group. Br. J. Haematol. 2025;19–757. doi: 10.1046/j. .2025. .x.

If numerous plasmacytomas are present, the diagnosis is multiple plasmacytomas and these cases fulfill the criteria for treatment of myeloma. If the pathological criteria for MM are met in the presence of abnormal plasmacytomas, the disease is defined as myeloma with plasmacytoma(s).

A multiple myeloma (also known as Kahler disease, myelomatosis and plasma cell myeloma) is a malignant neoplasm of plasma cells which is characterised by (1,2): Diagnostic criteria for MGUS (Monoclonal Gammopathy of Unknown Significance), asymptomatic myeloma and symptomatic myeloma; Differential diagnosis;

In 2025, the International Myeloma Working Group revised the diagnostic criteria for multiple myeloma. These new criteria add myeloma-defining events, the presence of any one of which is

The response criteria were established according to the 2025 Bologna criteria (Zamagni et al 23). Visual parameters based on the Bologna Italian Myeloma for PET Use

criteria for the diagnosis of MGUS, smouldering and symptomatic MM. Table 2: Diagnostic criteria according to the International Myeloma Working Group 2025[4]. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) SMOULDERING MYELOMA SYMPTOMATIC MYELOMA - Serum paraprotein 30g/l or

Imaging in myeloma is discussed in detail in recent UK and international guidelines.3,4 All diagnoses should be reviewed at a multidisciplinary team (MDT) meeting. Diagnostic Criteria Myeloma should be diagnosed using the 2025 IMWG updated criteria.5 Table II shows the diagnostic criteria for myeloma, smouldering (asymptomatic) myeloma and mono-

The revised International Myeloma Working Group (IMWG) criteria for the diagnosis of multiple myeloma and related disorders are shown on Table 1.1 The diagnosis of multiple myeloma

Smoldering multiple myeloma is a precursor or early sign that someone may develop multiple myeloma. Not everyone who has smoldering multiple myeloma develops multiple myeloma. When healthcare providers talk about criteria, they’re talking about test results that meet medical standards for making a certain diagnosis. The criteria for SMM are: