CONTENTS General considerations Approach to warfarin reversal Urgent reversal Non-urgent supratherapeutic INR Approach to DOAC reversal Dabigatran Factor Xa inhibitors (riveroXABAN, apiXABAN, edoXABAN, fondaparinux) Reversal of other agents Thrombolytics (e.g. tPA) Heparin reversal Antiplatelet agent reversal Pharmacology of broad-spectrum reversal agents Fresh Frozen Plasma (FFP) Prothrombin
Reversal Agents. The sedative classes of benzodiazepines (midazolam, lorazepam, diazepam) and opioids (meperidine, morphine, fentanyl) all have reversal agents
Reversal Agents. The sedative classes of benzodiazepines (midazolam, lorazepam, diazepam) and opioids (meperidine, morphine, fentanyl) all have reversal agents
reversal agents and experience with agents and dosing is limited o Properties (i.e. half-life, duration of action) of reversal agents/antithrombotics should
Reversal agents exist for each class of drugs used in sedative procedures (unfortunately, propofol does not have a reversal agent). The current reversal agents
CONTENTS General considerations Approach to warfarin reversal Urgent reversal Non-urgent supratherapeutic INR Approach to DOAC reversal Dabigatran Factor Xa inhibitors (riveroXABAN, apiXABAN, edoXABAN, fondaparinux) Reversal of other agents Thrombolytics (e.g. tPA) Heparin reversal Antiplatelet agent reversal Pharmacology of broad-spectrum reversal agents Fresh Frozen Plasma (FFP) Prothrombin
Unlike other sedation agents (e.g, midazolam, morphine), there is no reversal agent for propofol. Adverse effects must be treated until the drug is metabolized.
CONTENTS General considerations Approach to warfarin reversal Urgent reversal Non-urgent supratherapeutic INR Approach to DOAC reversal Dabigatran Factor Xa inhibitors (riveroXABAN, apiXABAN, edoXABAN, fondaparinux) Reversal of other agents Thrombolytics (e.g. tPA) Heparin reversal Antiplatelet agent reversal Pharmacology of broad-spectrum reversal agents Fresh Frozen Plasma (FFP) Prothrombin
Morphine, formerly also called morphia, [14] is an opiate that is found naturally in opium, (M5050, the reversing agent for the Immobilon dart) and nalorphine
Regards, Jack