Is allopurinol a high risk medication

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Actual: Allopurinol use did not associate with the risk of high-grade or metastatic cancer. Cumulative duration or average yearly dose of allopurinol use showed no association with PCa risk. No delayed risk associations were observed in the lag-time analyses.
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allopurinol or febuxostat) in patients at high risk of complications or Combination therapy with colchicine and NSAID or colchicine and

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HLA testing can identify individuals at high genetic risk of developing a severe cutaneous adverse reaction to allopurinol. treatment with allopurinol.

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The HLA-B5801 allele has been identified as a genetic risk factor for allopurinol allopurinol is begun, and a high fluid intake is advisable.

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by F Al-Ashkar Cited by 2neuropathy, myopathy (especially in renal insufficiency) allopurinol in populations at high risk for severe allopurinol hypersensitivity reaction.

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An increased risk of hypersensitivity has been reported when allopurinol is given with Extensive studies of high oral doses of allopurinol (up to 100

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If allopurinol treatment is stopped there is a high risk that your gout may worsen. In addition to treating gout, allopurinol is used to treat certain types

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People administered allopurinol for high uric acid levels occurring as a result of cancer are at a higher risk of developing kidney damage from allopurinol. There is a lack of data regarding the use of allopurinol during pregnancy or breastfeeding. Consider the risks versus benefits before starting.

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allopurinol is begun, and a high The HLA-B5801 allele has been shown to be associated with an increased risk of developing allopurinol

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Therefore, a possible conclusion from this study is that the ability of longstanding gout and a high uric acid concentration to identify a high risk group is little altered by long term low dose allopurinol. However, long term high dose allopurinol may be able to reverse that risk and return these patients to the risk normally found in patients

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