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The mean bioavailability of tramadol after a single oral dose is around 68% and increased to above 90% after multiple doses [3,31]. In healthy adult volunteers administered a 100 mg oral single dose of tramadol, the maximum plasma concentration (C max) was 308 g/l and was reached in 1.6 h (t max). The renal clearance was at 6.6 l/h .
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Tramadol/paracetamol combination tablet for postoperative pain following caffeine versus tramadol or placebo. JF Borel, C Deschaumes, L Devoize, C
The mean bioavailability of tramadol after a single oral dose is around 68% and increased to above 90% after multiple doses [3,31]. In healthy adult volunteers administered a 100 mg oral single dose of tramadol, the maximum plasma concentration (C max) was 308 g/l and was reached in 1.6 h (t max). The renal clearance was at 6.6 l/h .
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