Methadone receptors

☑️@methadone_receptors · 5148 subscribers · Content 18+ 🔞
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Actual: Methadone also activates the delta and kappa opioid receptors.[5,6] In addition to opioid receptor agonism, both R-methadone and S-methadone equally antagonize the N-methyl-D-Aspartate (NMDA) receptor. Since activation of NMDA leads to central sensitization, windup, and tolerance, methadone's blockage of this receptor can prevent and reverse
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