Nitrates sildenafil
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Viagra (sildenafil): The main contraindications to viagra (sildenafil) are nitrates . Flecanide and Lisinopril are ok.
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Nitrates are a tried-and-tested treatment for angina, but it's Nitrates should not be used with erectile dysfunction drugs such as sildenafil (Viagra).
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Remember to ask patients about nitrates used recreationally, e.g. amyl nitrate. Also remind patients who are using nitrates, that they must not take sildenafil. Sildenafil, through inhibition
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The difference in mechanisms between sildenafil and nitrates is Sildenafil inhibits the breakdown of cGMP, while nitrates increase production of cGMP. So, the option 1 is correct. Sildenafil and nitrates are medications used to treat cardiovascular conditions such as erectile dysfunction and angina, respectively.
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In conclusion, sildenafil potentiated the hypotensive effects of glyceryl trinitrate, an organic nitrate. Thus, sildenafil administration to patients who are using organic nitrates, either
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Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite (poppers). Taking sildenafil with a nitrate medicine can
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Sildenafil-nitrate interactions. Sildenafil-nitrate interactions. Sildenafil-nitrate interactions Prehosp Emerg Care. 2025 Oct-Dec;4(4):371. doi: 10.1080/ . Author R L Siegel. PMID: DOI: 10.1080/ No abstract available. Publication types
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Nitrates: Use of sildenafil is contraindicated in patients currently taking nitrate preparations. However, when nitrate administration becomes medically necessary, American College of
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sildenafil and nitrates - it is stated that these should not be used concurrently. nitrate therapy is an absolute contraindication to PDE5
Comments
Great story though....
To the commenter (Sex4lf57?) who said that Viagra doesn't work this way, I'll toss at least a cautionary comment or two.
Viagra is derived from a medication (sildenafil citrate) that was originally designed for cardiac patients. To prevent stress on the heart (that can cause a heart attack), the chemical causes the capillaries in the body to open as wide as possible, allowing the blood to flow freely with less pressure being applied by the heart.
As such, it also opens the capillaries in the corpus cavernosum of the penis, which leads to an erection. Now, there's a 'valve' that limits blood flow to the penis, so as to allow urinary function, without urine being able to seep into the passages where sperm travels. When a guy urinates, the semen passages are cut off - and when he is erect, the urinary tract is cut off, because the urethra (tube in the penis) does double duty.
When there is sufficient erotic stimulus to cause that 'valve' to switch the seminal tract to 'open', it also opens the sphincters that control blood flow to the penis, so that the capillaries can inflate completely.
During the years (nearly 60) that sildenafil citrate has been in use in cardiac patients (under another drug-name), it was noticed that when a patient was taking the drug, he was more susceptible (at an older age) to more-solid erections. Gradually, the doctors prescribing the drug got 'field reports' from their patients, and forwarded them to the company that makes the drug. Its use as an ED drug is secondary, and took a long time for FDA approval to market such a drug to non-cardiac patients.
When the person taking the drug is in their late teens or early 20's, and has a quite healthy circulatory system - and is around a near-continual erotic stimulus, as is the main character in this story - the effect CAN be a near-perpetual erection. Even the attempts to diminish it by masturbation won't necessarily cause it to go down, when there is a hotly-desired woman present and making subtle erotic comments to the male.