Baclofen for sleep dose

Baclofen and Sleep Patterns Baclofen can cause drowsiness and affect sleep patterns. It is important to establish a regular sleep routine and

In the RCTs using high-dose baclofen, insomnia or sleep disorders affected between 32.8% of the patients treated with high-dose baclofen, vs. between 14.8% of those receiving placebo (16, 18).

Evidence suggests that baclofen may offer sleep benefits by reducing sleep latency and increasing slow-wave sleep. The use of baclofen has also

by B Rolland Cited by 11neuropsychiatric baclofen-induced side effects. In the RCTs using high-dose baclofen, insomnia or sleep disorders affected between. 32.1 and

Regarding sleep outcomes, several variables were significantly improved by baclofen. Total sleep time and sleep efficiency increased, and wake after sleep onset decreased in the baclofen condition compared with placebo. Proportion of Stage 1 sleep was also significantly decreased on baclofen.

Baclofen usually helps these patients sleep better but in some patients, it has the opposite effect and makes it hard to get to sleep. This can be minimised by giving the last baclofen dose of the day at around 6pm so it covers the evening but is wearing off by bedtime.

The last dose of the day can be at bedtime if baclofen s anxiolytic effect helps sleep but others need to take the last dose around 5-6pm if baclofen causes sleeping problems. Watch for too great a gap between the afternoon and evening doses eg 6am, 1pm, 9pm.

Compared with oral baclofen, intrathecal baclofen infusion did not affect respiratory function and improved sleep continuity. Intrathecal baclofen infusion in therapeutic doses may act at the spinal level rather than at the supraspinal level.

Compared with oral baclofen, intrathecal baclofen infusion did not affect respiratory function and improved sleep continuity. Intrathecal baclofen infusion in therapeutic doses may act at the spinal level rather than at the supraspinal level.