Drugs that cause necrosis

Toxic doses of paracetamol may cause severe hepatocellular necrosis and, much less frequently, renal tubular necrosis. Nausea and vomiting, the early features

Podofilox (podophyllotoxin) is a patient-applied antimitotic drug that causes wart necrosis. Podofilox solution (using a cotton swab) or

Warfarin-induced skin necrosis refers to a rare condition in which there is paradoxical blood clotting. Blood clots block the blood vessels and cause necrosis.

Tumor Necrosis Factor Inhibitorsetanercept (Enbrel, adalimumab cause cessation of the drug. Because leflunomide and its metabolites are a

Extravasation is the inadvertent leakage of vesicant drug or solution into the tissues surrounding an intravenous (IV) site. Vesicant is an agent that can cause blistering or tissue necrosis when extravasated. Irritant is an agent that can cause a local inflammatory reaction but does not cause tissue necrosis when extravasated.

Anti-TNF drugs target a protein called 'tumor necrosis factor' that causes inflammation. These drugs suppress the immune system and reduce

The period of time that it takes to develop avascular necrosis will largely depend on the cause. For example, for drugs such as prednisone or chemotherapy drugs to be present in sufficient quantities in a person s bloodstream to be able to cause avascular necrosis, they need to be taking such drug for an extended period of time (usually over a number of months).

Biologic drugs, such as tumour necrosis factor inhibitors (TNFi), work by reducing or eliminating certain proteins that cause inflammation.

There are a number of drugs that cause direct toxicity to the renal tubules (acute tubular necrosis) - eg, aminoglycosides, amphotericin and ciclosporin. Drugs