Levothyroxine and ppi

Consider the alteration in gastric pH caused by the PPI. Some authorities recommend separating administration of PPI and levothyroxine by several hours, however

One study found that replacing levothyroxine tablets with an oral solution improved levothyroxine absorption in the presence of PPIs. 8.

Iron supplements themselves can also decrease levothyroxine absorption. Tapering to stop any unnecessary PPI use, and rescheduling doses of the PPI, oral iron

Co-administration of levothyroxine with PPIs (such as omeprazole, esomeprazole, pantoprazole, rabeprazole, and lanzoprazole) may decrease

Co-administration of levothyroxine with PPIs (such as omeprazole, esomeprazole, pantoprazole, rabeprazole, and lanzoprazole) may decrease

Co-administration of levothyroxine with PPIs (such as omeprazole, esomeprazole, pantoprazole, rabeprazole, and lanzoprazole) may decrease

The frequency of a concomitant ingestion of levothyroxine and PPI could be Like levothyroxine, PPIs are usually taken fasting before breakfast

Drug-drug interactions between levothyroxine and St. John's Wort and between levothyroxine and proton- pump inhibitors (PPIs) may alter

Important Note: if you are taking PPIs and being treated for hypothyroidism, be aware that tablet forms of levothyroxine are significantly less effective when you are taking a PPI. The gel cap and liquid form of levothyroxine (Tirosint and Tirosint-SOL) were designed to be absorbed well by patients taking PPIs.