Case 2: electrocardiogram at admission (A) with QTc 720 ms and at discharge (B) with QTc 410 ms. promethazine and ondansetron, 89 or antidepressants could
buprenorphine, long-acting injection and promethazine both decrease QTc interval. For motion sickness, the first dose of promethazine should be used 30 to 60
promethazine. buprenorphine and promethazine both decrease QTc interval. Avoid or Use Alternate Drug. propafenone.
There is little data to suggest that promethazine, prochlorperazine, and metoclopramide increase QTc as low dose monotherapy, however when given with other QTc prolonging meds, can contribute to QTc prolongation. For agents that have QTc prolonging effects, most of the risk is associated with higher doses
Use Caution/Monitor. promethazine. promethazine and azithromycin both increase QTc interval. Use Caution/Monitor. propafenone. azithromycin increases toxicity
promethazine and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely. gabapentin. gabapentin, promethazine. Either increases effects of the
prolong the QTc interval. Expert Opin Drug Saf, 1, p. ; Cerner Multum Applies to: dextromethorphan / promethazine and dextromethorphan / promethazine.
The optimal time to measure QTc is when the QTc-prolonging medication is at steady state. Promethazine (Phenergan). Trazodone (Desyrel). Clozapine (Clozaril).
Ondansetron may contribute to QTc prolongation when administered intravenously There is little data to suggest that promethazine
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