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Author: Admin | 2025-04-28
Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 11, 2024. How it worksUpsidesDownsidesBottom LineTipsResponse/effectivenessInteractions 1. How it works Hydrochlorothiazide is a diuretic (this means it increases urination) that works by inhibiting the reabsorption of salts in the kidneys. Hydrochlorothiazide also lowers blood pressure in people with high blood pressure by an unknown mechanism; people with normal blood pressure are not usually affected by hydrochlorothiazide.Hydrochlorothiazide belongs to the class of medicines known as thiazide diuretics. Hydrochlorothiazide may be abbreviated as HCTZ. 2. Upsides Hydrochlorothiazide is used in addition to other drugs to remove fluid build-up (edema) in the body caused by heart failure, liver disease, renal disease, and steroid or estrogen therapy. May be used to treat edema due to nephrotic syndrome that has not responded to corticosteroids. Intermittent (as needed) therapy may be appropriate for some people with edema. Used to lower blood pressure in people with high blood pressure; daily dosing is usually recommended when hydrochlorothiazide is used for this indication.May be used off-label for several other indications.May be used alone or in combination with other agents.Orthostatic hypotension ( a drop in blood pressure when going from a lying to a sitting or standing position) rarely occurs.Generic hydrochlorothiazide is available. 3. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: A headache, dizziness on standing, dehydration, skin reactions, and depletion of electrolytes are the most common
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