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Author: Admin | 2025-04-28
Often suspected of contributing to GERD when people respond incompletely or not at all to powerful acid-suppressant medications. Barrett's esophagus. This serious condition can occur when long-term exposure to stomach acid, or to acid and bile, damages tissue in the lower esophagus. The damaged esophageal cells have an increased risk of becoming cancerous. Animal studies have also linked bile reflux to Barrett's esophagus. Esophageal cancer. There's a link between acid reflux and bile reflux and esophageal cancer, which may not be diagnosed until it's quite advanced. In animal studies, bile reflux alone has been shown to cause cancer of the esophagus.Townsend CM Jr, et al. Stomach. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 20th ed. Elsevier; 2017. https://www.clinicalkey.com. Accessed Jan. 15, 2020.Brunicardi FC, et al., eds. Stomach. In: Schwartz's Principles of Surgery. 11th ed. McGraw-Hill; 2019. https://accessmedicine.mhmedical.com. Accessed Jan. 16, 2020.Acid reflux (GER & GERD) in adults. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults/all-content. Accessed Jan. 15, 2020.Rakel D, ed. Gastroesophageal reflux disease. In: Integrative Medicine. 4th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Jan. 15, 2020.Hammer GD, et al., eds. Gastrointestinal disease. In: Pathophysiology of Disease: An Introduction to Clinical Medicine. 8th ed. McGraw-Hill; 2019. https://accessmedicine.mhmedical.com. Accessed Jan. 16, 2020.McCabe ME, et al. New causes for the old problem of bile reflux gastritis. Clinical Gastroenterology and Hepatology. 2018; doi:10.1016/j.cgh.2018.02.034.Caspa Gokulan R, et al. From genetics to signaling pathways: Molecular pathogenesis of esophageal adenocarcinoma. Biochimica et Biophysica Acta. Reviews on Cancer. 2019; doi:10.1016/j.bbcan.2019.05.003.Khanna S,
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