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Author: Admin | 2025-04-28
"Drug-grapefruit juice interactions." Mayo Clin Proc 75 (2000): 933-42 The following applies to the ingredients: Amlodipine Professional Content This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus (AU, US)Use is contraindicated (UK)AU TGA pregnancy category: CUS FDA pregnancy category: CComments:-Use of adequate methods of contraception should be encouraged.-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.Animal studies have shown significantly decreased litter size, increased intrauterine deaths and prolongation of gestation and duration of labor when this drug was given before mating, throughout mating, and during gestation. There are no controlled data in human pregnancy. Reversible biochemical changes in the head of spermatozoa occurred in some patients treated with calcium channel blockers. There are no controlled data for this drug, but animal models have shown adverse effects on male fertility.AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. References "Product Information. Norvasc (amlodipine)." Pfizer U.S. Pharmaceuticals PROD (2002): Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 The following applies to the ingredients: Amlodipine Professional Content Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother (AU, US)Use is contraindicated (UK)Excreted into human milk: YesComments: -The effects in the nursing infant are unknown.-Infants exposed to this drug should be closely monitored. References "Product Information. Norvasc (amlodipine)." Pfizer U.S. Pharmaceuticals PROD (2002): Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013): No warnings were found for your selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Switch to: Professional Interactions Drug Interaction Classification These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate
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