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Author: Admin | 2025-04-28
Cause severe skin reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which may be fatal.Use with caution in people with asthma or with aspirin-sensitive asthma as bronchospasm may occur and cross-reactivity between aspirin and other NSAIDs (such as Celebrex) has been reported. Rarely, life-threatening hypersensitivity reactions may trigger allergy-like asthma. Not suitable for use in certain people (such as those with severe liver disease; poor metabolizers of CYPD2C9 substrates; allergic to sulfonamides, aspirin, or other NSAIDs; active gastrointestinal bleeding) or after certain procedures, such as following coronary artery bypass graft (CABG) surgery. Do not use at the same time as other non-aspirin NSAIDs. May interact with several other drugs including warfarin, lithium, fluconazole, and ACE inhibitors. Should not be used for pain relief during coronary artery bypass graft (CABG) surgery or given in late pregnancy (from 20 weeks gestation).Expensive compared to most other NSAIDs.Only available on prescription (many NSAIDs are available over-the-counter). Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects 4. Bottom Line Celebrex is a COX-2-specific NSAID that has a lower propensity for gastrointestinal side effects than many other NSAIDs; however, it still may increase the risk of serious cardiovascular thrombotic events. Celebrex is a sulfonamide and is not suitable for people with sulfonamide allergies. Pregnant women should not use NSAIDs at 20 weeks or later in pregnancy unless advised to do so by their healthcare professional. 5. Tips May be given with or without food, although dosages above 400mg twice daily should be administered with food to improve absorption. Seek immediate medical advice if you develop any chest pain, shortness of breath, weakness, slurring of speech, dyspepsia, or blood in your stool. Also seek urgent medical attention if you develop unexplained nausea, fatigue, itching, skin yellowing, right upper abdominal pain tenderness, or flu-like symptoms. Tell your doctor if you have asthma or a history of rhinitis or hay fever before you take Celebrex. If you have asthma and your asthma worsens after taking Celebrex, seek urgent medical advice. Use the lowest effective dose for the shortest duration of time. Celebrex is a sulfonamide and can cause serious skin effects. Stop Celebrex immediately if any type of rash develops and contact your doctor as soon as possible. Report any unexplained weight gain or fluid retention to your doctor. Twice daily dosing is recommended; more frequent dosing does not necessarily improve response. Response to different NSAIDs can vary so switching types (for example, from Celebrex to naproxen) may improve response.NSAIDs should
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