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Author: Admin | 2025-04-28
Of hypertension.Extemporaneous Liquid FormulationAn oral liquid formulation containing 2 mg/mL of atenolol has been extemporaneously prepared using the commercially available tablets and various vehicles (e.g., simple syrup, Ora-Sweet, Ora-Plus, Ora-Sweet SF, methylcellulose-based vehicle). Standardize 4 SafetyStandardized concentrations for an extemporaneously prepared oral liquid formulation of atenolol have been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. Because recommendations from the S4S panels may differ from the manufacturer’s prescribing information, caution is advised when using concentrations that differ from labeling, particularly when using rate information from the label. For additional information on S4S (including updates that may be available), see [Web].Table 2: Standardize 4 Safety Compounded Oral Liquid Standards for Atenolol275Concentration Standards2 mg/mLDosagePediatric PatientsHypertension†OralSome experts have recommended an initial dosage of 0.5–1 mg/kg daily given as a single dose or in 2 divided doses. Increase dosage as necessary up to a maximum dosage of 2 mg/kg (up to 100 mg) daily given as a single dose or in 2 divided doses.AdultsHypertensionAtenolol TherapyOralInitially, 50 mg once daily, alone or in combination with a diuretic recommended by manufacturer; full hypotensive effect usually seen within 1–2 weeks. If necessary, may increase dosage to 100 mg once daily.Usual dosage range: Some experts state 25–100 mg daily, administered in 2 divided doses.Atenolol/Chlorthalidone Fixed-combination TherapyOralInitially, 50 mg of atenolol and 25 mg of chlorthalidone once daily. If response is not optimal, 100 mg of atenolol and 25 mg of chlorthalidone once daily.Manufacturer states fixed-combination preparation is not recommended for initial therapy; administer each drug separately, then use the fixed combination if the optimum maintenance dosage corresponds to the ratio of drugs in the combination preparation. May add another antihypertensive agent when necessary (gradually using half of the usual initial dosage to avoid an excessive decrease in BP).Chronic Stable AnginaOralInitially, 50 mg once daily.If optimum response is not achieved within 1 week, increase to 100 mg once daily.Some patients may require 200 mg once daily for optimum effect.Acute MIEarly TreatmentMay initiate therapy as soon as possible after patient’s hemodynamic condition has stabilized.In patients with definite or
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