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Author: Admin | 2025-04-28
Medication NameContrave*image for illustrative purpose onlyVyvanse*image for illustrative purpose onlyContrave*image for illustrative purpose onlyVyvanse*image for illustrative purpose onlySummaryPrescription onlyContrave® (naltrexone hydrochloride and bupropion hydrochloride) is a prescription medication used for weight management in adults, combining two active ingredients: naltrexone, which affects the brain's reward system, and bupropion, which influences appetite and cravings. It works by targeting the hypothalamus to reduce hunger and the mesolimbic reward system (a pathway in the brain that plays a key role in regulating feelings of pleasure, motivation, and reinforcement) to curb food cravings. Contrave is FDA-approved for chronic weight management. Common side effects include nausea, constipation, headache, and insomnia, while drug interactions can occur with MAO inhibitors, opioid pain medications, and drugs that lower the seizure threshold. Contrave carries a boxed warning for an increased risk of suicidal thoughts and behaviors, particularly in young adults, due to its bupropion component.Prescription onlyVyvanse® (lisdexamfetamine) is a stimulant medication used to treat attention-deficit hyperactivity disorder (ADHD) and binge eating disorder (BED) by increasing available levels of dopamine and norepinephrine in the brain, which helps improve focus, attention, and impulse control. Its FDA-approved indications include the treatment of ADHD in patients 6 years and older and moderate to severe binge eating disorder in adults. Vyvanse is available in capsule and chewable tablet forms, typically taken once daily in the morning. Common side effects include decreased appetite, insomnia, dry mouth, and increased heart rate, with serious risks including potential cardiovascular issues and psychiatric side effects like anxiety. Vyvanse carries a boxed warning for the high risk of abuse, dependence, and serious cardiovascular events, particularly in individuals with a history of heart problems.Drug CategoryNaltrexone: opioid antagonistBupropion: aminoketone antidepressantCentral nervous system (CNS) stimulantApproved UsesContrave (naltrexone hydrochloride and bupropion hydrochloride) is indicated:As an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:30 kg/m2 or greater (obese)27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)Vyvanse (lisdexamfetamine dimesylate) is indicated for the treatment of:Attention deficit hyperactivity disorder (ADHD) in adults and pediatric patients 6 years and olderModerate to severe binge eating disorder (BED) in adultsDosageTypically taken orally twice dailyComes as 8 mg/90 mg extended-release tabletsTypically taken orally once dailyComes in 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg capsules and 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg chewable tabletsKnown Common Side EffectsMost common adverse reactions (greater than or equal to 5%):NauseaConstipationHeadacheVomitingDizzinessInsomniaDry mouthDiarrheaMost common adverse reactions (incidence ≥5% and at a rate at least twice placebo) in pediatric patients ages 6 to 17 years, and/or adults
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