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Author: Admin | 2025-04-28
Diarrhea-predominant IBS. Symptoms of IBS-D may include:Frequent and/or severe stomach painUrgent need to have bowel movements or accidentsRestriction of normal daily activities due to IBS The following prescription drugs are recommended for managing IBS-D by experts at the American Gastroenterological Association. Alosetron The Food and Drug Administration (FDA) approved Lotronex (alosetron) for use in adult females with chronic IBS-D who’ve had IBS symptoms for at least six months and haven’t responded to other treatments. This medication is not approved for use in children or adult males, as it has not been shown to be effective in these populations. Alosetron comes in an oral tablet, with a typical starting dosage of 0.5 mg twice daily. After four weeks, the dose may be increased to 1 mg twice daily. If this dosage doesn’t help control your IBS symptoms within four weeks, your healthcare provider will likely have you stop the medication. Common side effects of alosetron include constipation, abdominal pain, and nausea. Rare but serious complications may occur as a result of prolonged constipation. Reach out to a healthcare provider if constipation lasts longer than usual or results in pain. People with constipation problems and those taking a medication called fluvoxamine should not take alosetron. Eluxadoline Viberzi (eluxadoline) is another treatment option for IBS-D. This prescription-only medication is FDA-approved for use in adults. Eluxadoline comes as an oral tablet. The typical dosage is 100 mg twice a day. A lower dosage of 75 mg twice daily is recommended for people with liver or kidney problems, those unable to tolerate the 100 mg dose, and those taking certain medications that interact with eluxadoline, such as Neoral (cyclosporine). Common side effects of eluxadoline are constipation, nausea, and abdominal pain. If severe constipation occurs, contact a healthcare professional right away. Eluxadoline is not a safe option for everyone and shouldn’t be taken by individuals with:Constipation problemsGallbladder or biliary duct problemsHistory of pancreatitis (inflammation in the pancreas)Frequent alcohol use or alcohol use disorder Rifaximin Xifaxan (rifaximin) is a prescription-only antibacterial drug that is FDA-approved for the short-term treatment of IBS-D in adults. This medication is also
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