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Author: Admin | 2025-04-28
Needed, but recent studies suggest that when taken together, cannabis and gabapentin may complement one another in treating neuropathic pain.In 2019, a study was conducted on mice over eight days in which the researchers administered a fixed dose of THC and gabapentin. Their findings indicate that when combined, THC and gabapentin can create a larger therapeutic window than just THC alone, leading researchers to conclude that THC may be a complementary substance when taken with neuropathic medications like gabapentin.¹A more recent 2022 study in Denmark observed about 1800 individuals using cannabis for neuropathic pain and other unspecified pain. Researchers concluded that cannabis is generally safe for those with neuropathic pain but may not be as safe for those with unspecified pain disorders.² Specifically, individuals who consumed THC were found to use more opioids, but those with neuropathic pain who consumed THC, CBD, or both were found to use less gabapentin. Controlled research studies regarding how cannabis and gabapentin interact are still minimal.Gabapentin has been predominantly prescribed for treating and reducing seizures, and cannabis has been studied for those same benefits. It’s not surprising to see that, despite a lack of clinical research, individuals often attribute cannabis to reducing their need for medications like gabapentin. Personal stories on websites like Reddit catalog unique experiences describing how cannabis usage has not only drastically reduced their number of seizures per month but also helped them to remove gabapentin from their list of needed medications. Further research is required to understand how gabapentin and cannabis interact with the human neurological system. The Complete Guide to Medical Cannabis for Stress & Anxiety Find natural, lasting relief with our comprehensive (and completely free) patient’s guide to medical cannabis for stress and anxiety. Potential Risks of Mixing Marijuana and GabapentinIt is still unclear how cannabis and gabapentin work in unison with one another. So far, researchers and individuals have mainly found that cannabis helps to reduce the need for neuropathic medications like gabapentin in some situations. Gabapentin has been studied for its ability to alleviate withdrawal symptoms from cannabis dependence. This evidence may indicate that gabapentin operates on similar neural pathways as THC, suggesting that it may decrease the endocannabinoid system’s reliance on cannabis. Researchers in 2012 observed 50 people aged 18-65 with cannabis dependence. They found that gabapentin was an acceptable and safe treatment method for cannabis withdrawal symptoms but noted several limitations that call for further studies to confirm the findings.³ While gabapentin may reduce withdrawal symptoms, there is still little research regarding how cannabis and gabapentin interact in the body, and combining substances under any circumstance has the potential for adverse outcomes. According to the National Health Services, gabapentin can intensify the intoxicating effects
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