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Author: Admin | 2025-04-28
Ibuprofen (Advil) is a nonsteroidal anti-inflammatory drug (NSAID) that’s commonly used to help reduce pain, fever, and inflammation. It has the potential to be harmful for your kidneys and liver, but the risk is higher in certain people.Ibuprofen can cause acute kidney injuryIbuprofen can reduce blood flow to the kidneys, which may lead to kidney damage. While you might not notice anything from mild kidney injury, as things get worse you could experience any of the following symptoms:Producing less urine or not urinating at allSwelling in your arms, legs, or feetItchy skinNauseaConfusionWeaknessIf you notice any of the above symptoms while taking ibuprofen, contact your doctor right away. Once ibuprofen is stopped, the kidneys usually recover in most people.Ibuprofen can cause liver damageAlthough rare, ibuprofen can sometimes cause liver damage. According to the product label, up to 15% of people taking NSAIDs (including ibuprofen) have had a rise in their liver enzyme tests. This suggests liver injury. However, only 1% of people during clinical studies experienced a significant rise of liver enzymes (≥3 X upper limit of normal). It’s estimated that there’s about 1-2 cases of liver injury due to ibuprofen out of 100,000 prescriptions. Occasionally, liver injury is seen after experiencing a severe allergic reaction from ibuprofen.The risk of liver injury while taking ibuprofen appears to increase with higher doses of 2,400 to 3,200 mg daily. In most cases, the effects on the liver are reversible after stopping ibuprofen.It’s not fully clear how ibuprofen causes liver damage. One theory is that it’s caused by a metabolite (a substance produced during the metabolism of ibuprofen in the body). Another is that it could be caused by an immune system reaction.While taking ibuprofen, watch out for signs and symptoms of liver damage, which may include:Pain in the upper right side of your
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