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Author: Admin | 2025-04-28
Be agood option. Methylphenidate is not extensively metabolized by CYP enzymes likeCYP2D6. ADHD Treatment OptionsIn terms of treatment for ADHD, there are two categories ofdrugs: stimulants and non-stimulants. Stimulants include dextroamphetamine/amphetamine(Adderall), methylphenidate (Ritalin, Concerta), and dexmethylphenidate(Focalin). The most popular nonstimulant is atomoxetine (Strattera), but guanfacine(Intuniv) and clonidine are also considered nonstimulants.Both stimulants and nonstimulants have an impact on neurotransmitterswhich leads to the calming effect with hyperactivity. Stimulants are generally usedas the first-line treatment option in most cases. Stimulants have been used inpractice longer and therefore have more evidence than the nonstimulants.Nonstimulants are generally considered less prone to abuse and are not controlledsubstances. There is not enough evidenceto support improved efficacy of one drug over another as response depends onindividual factors.Both stimulants and nonstimulants can cause upset stomach,irritability, and weight loss. Stimulants are more prone to cause headaches,cardiac problems in patients with pre-existing cardiac conditions, andinsomnia. The potential also exists of an increased risk of suicidal ideationwith both classes, although a black box warning exists with Strattera.If you feel your dose is not working for you it is worthdiscussing with your physician your concerns. The dose may need to beincreased, assuming the dose has been tried for at least a week. Adderall hasbeen studied in doses up to 60 mg/day. Other options include changingmedications to other stimulants or nonstimulants as you may respond differentlyto each drug. Source: Adderall Package Insert
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