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Author: Admin | 2025-04-28
For moderate nausea and vomiting due to chemotherapy, take 4 mg of ondansetron (Zofran) 30 minutes before the start of chemotherapy, followed by another 4 mg dose given at 4 and 8 hours after the first dose. After the completion of chemotherapy, take 4 mg of ondansetron (Zofran) every 8 hours for 1 to 2 days.Age 12 to 17: For moderate nausea and vomiting due to chemotherapy, take 8 mg of ondansetron (Zofran) 30 minutes before the start of chemotherapy, followed by another 8 mg dose given 8 hours after the first dose. After the completion of chemotherapy, take 8 mg of ondansetron (Zofran) every 12 hours for 1 to 2 days.Precautions:People with severe liver disease should not take more than 8 mg of ondansetron in a day.Zofran is not approved by the FDA to be used during pregnancy. However, there are studies that show Zofran’s safety in treating morning sickness during the first trimester. You should discuss with your doctor if you are pregnant or breastfeeding. Do not give Zofran to children younger than 4 years old. When can I take Zofran again? After 4 HoursIn certain instances, Zofran can be administered every 4 hours. For children, a 4 mg or 8 mg dose of Zofran is given 30 minutes before chemotherapy (4 mg for ages 4-11 years and 8 mg for ages 12-17 years). Two subsequent doses are given at 4-hour intervals, followed by a dose every 8 hours for 1-2 days after chemotherapy.After 6 HoursThe typical adult dose of Zofran is 8 mg every 8-12 hours or 2-3 times a day. You could take it more frequently, such as every 6 hours, if the dose is less than 8 mg. But the total dose should not exceed 8 mg in the specified timeframe. Adhering to the prescribed schedule of Zofran is important. Consult your healthcare provider before making any dosing adjustments if your nausea and vomiting are not controlled. After 8 HoursZofran is limited to every 8 hours because clinical trials have revealed an increased risk of QT prolongation, an abnormality in the heart’s electrical system. The risk of QT prolongation is dose-related. Doctors avoid intravenous (IV) doses above 16 mg and oral Zofran intake is limited to every 8 hours at home for this reason.What are the risks associated with Zofran use?Severe allergic reactionsIn a small number of people, Zofran can cause severe allergic reactions with difficulty breathing, swelling of the throat, skin rash, hives, and itching. Stop taking ondansetron (Zofran) and seek immediate medical attention if you develop signs and symptoms of an allergic reaction.Serotonin syndromeExcessive ondansetron (Zofran) intake can lead to serotonin syndrome, a potentially life-threatening condition caused by elevated serotonin levels in the
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