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Author: Admin | 2025-04-28
Indications, Uses, Dosage, Drugs Interactions, Side effectsOverview L-arginine Medicine Type : Allopathy Prescription Type: OTXApproval :FSSAI (Food Safety and Standards Authority of India)Pharmacological Class:Non-essential amino acid, Therapy Class:Nutrition, About L-arginineL-arginine is a belonging amino acid belonging to the non-essential amino acid class. L-arginine is also known as (S)-2-Amino-5-guanidinopentanoic acid, Arg and Arginine. L-arginine is a cofactor for several enzymes involved in procedures, including sulphur metabolism and detoxifying certain substances essential for optimal well-being. L-arginine deficiency is very uncommon in humans. It may lead to decreased sulfite oxidase activity and sulfite toxicity in a patient receiving long-term complete parenteral nutrition. Symptoms like tachycardia, tachypnea, headache, nausea, vomiting, and coma characterize it. The highest amount of dietary L-arginine is found in dietary protein, commonly in meat, fish, poultry, milk, dairy products, nuts, and seeds. Other dietary sources include barley, brown rice, buckwheat, chocolate, corn, oats, raisins and soy. The stomach absorbs arginine into circulation, where it is subsequently transported to cells. It is metabolised by enzymes to produce nitric oxide (NO), which has functions in signalling, immunity, and vasodilation. The kidneys are used to remove extra arginine. The common side effects of L-arginine include diarrhoea, headaches, nausea, diarrhoea, headaches and abdominal pain. L-arginine is available in injectable solutions and oral powders. Mechanism of Action of L-arginineBiochemical action of L-arginine L-arginine belonging to the supplement class helps in several enzymatic processes. L-arginine acts via L-arginine enzyme-mediated biochemical pathways. Arginine is a significant component in several biochemical processes that have a variety of consequences, including pH control, depolarization of endothelial cell membranes, immunity, and anticancer activity. It is a vital component in the urea cycle and the metabolism of macronutrients. Additionally, corticotropin-releasing factors, insulin, glucagon, prolactin, aldosterone, and somatostatin, are among the hormones whose release is influenced by arginine. Growth hormone and immune function: Arginine stimulates the secretion of growth hormone, which consequently boosts the cytotoxic activity of neutrophils, macrophages, natural killer cells, and cytotoxic T lymphocytes. Nitric oxide (NO)production: Given that NO plays several functions in various organs, the arginine-NO pathway, a subset of arginine metabolism, is important. In mammalian cells, NOS causes the radical chemical NO to be produced from l-arginine. It has a global effect and affects host defence, gene expression regulation, inflammation, and neurotransmission. Antiobesity: L-arginine supplementation improves metabolic profiles, decreases white adipose tissue, and promotes the formation of brown adipose tissue. As a result, it shows potential for managing and preventing obesity. How To Use L-arginineL-arginine is available in injectable solutions and oral powders. Injectable solutions: To be administered parenterally, as applicable.Powders, oral: Powders must be mixed thoroughly with the appropriate amount of liquid and stirred well to dissolve the powder, as applicable. Uses of L-arginineL-arginine can be used as a supplement when the amount of L-arginine taken from the diet is insufficient. L-arginine supplements taken by IV may be used to prevent and treat L-arginine deficiency, a condition in which the body needs L-arginine. The L-arginine supplement helps the body break down medicines, ingested harmful compounds, proteins and
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