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Author: Admin | 2025-04-28
17, 1998. Celexa is manufactured by Forest Pharmaceuticals, Inc. Lexapro (Escitalopram oxalate) is the newest and most selective of the SSRIs approved by the FDA in August 14, 2002. Lexapro is manufactured by Forest Pharmaceuticals, Inc. Lexapro is a cleaner, improved version of Celexa. It is the active isomer of racemic citalopram. Brief SSRIs comparison table Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil) Sertraline (Zoloft) FDA approval date July 17, 1998 August 14, 2002 December 29, 1987 December 29, 1992 December 30, 1991 Pharmaceutical Forms 10mg, 20mg, 40mg tablets, oral solution 10 mg/5 mL 5mg, 10mg, 20mg tablets, oral solution 5 mg/5 mL 10mg tablets, 10mg, 20mg, 40mg pulvules, oral solution 20mg/5mL, weekly capsules 90 mg 10mg, 20mg, 30mg, 40mg tablets, oral suspension 10 mg/5 mL 25mg, 50mg, 100mg tablets, oral concentrate 20 mg/mL Recommended dose (for Major Depressive Disorder) 20-40 mg/day 10–20 mg/day 10-20 mg/day 20 mg/day 50-100 mg/day Drug interaction potential Relatively low Relatively low High Moderate to high Relatively low Most common side effects Nausea Dry mouth Drowsiness Insomnia Increased sweating Diarrhea Nausea Insomnia Diarrhea Headache Nausea Headache Insomnia Nervousness Anxiety Drowsiness Anorexia Diarrhea Nausea Drowsiness Headache Dry mouth Dizziness Weakness Fatigue Sexual dysfunction Increased sweating Diarrhea Insomnia Nausea Headache Insomnia Diarrhea Dry mouth Sexual dysfunction (ejaculation failure, decreased libido) Drowsiness Dizziness Fatigue Less common side effects Tremor Sexual dysfunction (abnormal ejaculation, decreased libido, impotence) Fatigue Anxiety Agitation Anorexia Sexual dysfunction (abnormal ejaculation, decreased libido, impotence) Dry mouth Drowsiness Fatigue Increased sweating Dizziness Anxiety Anorexia Dizziness Weakness Dry mouth Anxiety Agitation Tremor Increased sweating Sexual dysfunction Tremor Constipation Decreased appetite Anxiety Nervousness Tremor Increased sweating Agitation Anorexia Nervousness Anxiety Pharmacokinetic Variables Half-life 35 hours 27–32 hours 2-4 days 20 hours (highly variable) 26 hours Oral bioavailability 80% 51-93% 70% 50% 20-36% Time to steady-state 7 days 7 days 30 to 60 days 10-14 days 7-14 days Active Metabolite? N-Desmethylcitalopram O-Desmethyl-fluoxetine, norfluoxetine N-desmethyl Mechanism of action The brain communicates with itself through the use of special chemicals called neurotransmitters, such as serotonin and norepinephrine. Neurotransmitters carry signals from one nerve cell to another. Research suggests that abnormalities
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