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Author: Admin | 2025-04-28
Of action.Because Lexapro interacts with CYP450 enzymes such as: CYP2C19; CYP2D6; and CYP3A4 – any co-administered substance that also interacts with these enzymes could alter the rate at which Lexapro is metabolized. For example, concurrent administration of a medication that suppresses CYP2C19 function might result in much higher systemic concentrations of Lexapro than expected, leading to a faster onset of action (and likely more side effects).Conversely, the concurrent administration of a medication that enhances CYP2C19 function might result in lower systemic concentrations of Lexapro than expected, leading to a slower onset of action (or possibly no noticeable effect). Additionally, certain medications may augment Lexapro pharmacodynamically such as by bolstering its neurochemical effect and/or induction of neurophysiologic adaptations (e.g. upregulation of BDNF).Other medications might counteract the pharmacodynamics of Lexapro and reduce its neurochemical effect, ultimately delaying its onset of action – or preventing it from working. Reflect upon any substances that you’re using with Lexapro and realize that they might be a reason as to why its onset of action was quicker or slower than expected.Source: https://www.ncbi.nlm.nih.gov/pubmed/17375980Preexisting medical conditionsA variety of preexisting medical conditions might influence how long it takes Lexapro to start working. For example, some individuals diagnosed with bipolar disorder may report a rapid onset of antidepressant action associated with Lexapro – such that the medication provokes mania (BP1) or hypomania (BP2). It is thought that certain neurochemical underpinnings of bipolar disorder may increase likelihood of rapid SSRI action.Individuals with medical conditions like hepatic dysfunction or renal impairment might
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