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Author: Admin | 2025-04-28
May be prescribed. They all can be taken in combination with a statin.Ezetimibe (cholesterol absorption inhibitors) Prevents cholesterol from being absorbed in the intestine. It’s the most commonly used non-statin agent.Bile acid sequestrantsAlso called bile acid-binding agents, cause the intestine to get rid of more cholesterol. Those available in the U.S. include: Cholestyramine (Questran®, Questran® Light, Prevalite®, Locholest®, Locholest® Light) Colestipol (Colestid®) Colesevelam Hcl (WelChol®)PCSK9 inhibitorsPCSK9 inhibitors are powerful LDL-lowering drugs. They bind to and inactivate a protein on cells found in the liver to lower LDL (bad) cholesterol. Some names are alirocumab and evolocumab.Adenosine triphosphate-citrate lyase (ACLY) inhibitors*ACLY inhibitors work in the liver to block the production of cholesterol. They are used in combination with lifestyle changes and statins to further decrease LDL cholesterol in adults with hereditary high cholesterol and people with heart disease who need to further lower their LDL. Bempedoic acid (Nexletol) Bempedoic acid and ezetimibe (Nexlizet)*Adenosine triphosphate-citrate lyase (ACLY) inhibitors are not in the current Guideline on the Management of Blood Cholesterol, as they were FDA approved in 2020. For more information on ACL inhibitors visit the National Library of Medicine(link opens in new window).The following triglyceride-lowering drugs have mild LDL-lowering action, but data doesn’t support their use as an add-on treatment to statins.FibratesFibrates are especially good for lowering triglyceride (blood fat) levels and have a mild LDL-lowering action. Fibrates available in the U.S. include: Gemfibrozil (Lopid®) Fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide™) Fenofibric Acid (Fibricor® and Trilipix®)Niacin (nicotinic acid)Niacin is a B vitamin that limits the production of blood fats in the liver. Take this only if your health care professional has prescribed it. It lowers triglycerides and has mild LDL-lowering action.Niacin side effects may include flushing, itching and upset stomach. Your liver functions may be closely monitored because niacin can cause toxicity. Nonprescription
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