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Author: Admin | 2025-04-28
Can control the amount of stomach acid and neutralise it. When one or both of these mechanisms go awry, stomach lining damage and ulceration can occur. Typical over-the-counter doses of ibuprofen are up to 1200mg per day and can be taken for up to three days. Max Mozart/Flickr, CC BY Ironically, due to their pain-relieving properties, NSAIDs can cause serious damage to stomach lining. This is because they decrease pain and inflammation by inhibiting production of prostaglandins, a group of fatty acids that promote inflammation and increase pain perception.But prostaglandins also protect the stomach lining from acid, by decreasing acid production and increasing mucus secretion and its neutralising properties. So inhibiting prostaglandins also reduces their protective functions. NSAIDs are commonly used to manage the pain and inflammation of arthritis and musculoskeletal disorders. People also take them for short-term pain relief: for headaches, migraines and period pain, as well as to reduce fever. There’s an important difference between the risk to long-term users compared to someone who takes them for the occasional headache.Gastric ulceration, where irritation to the stomach erodes its surface, can be severe. Symptoms include internal bleeding, indigestion, nausea, vomiting and weight loss. Studies show that, in relation to NSAIDs, ulceration is time- and dose-dependent. Typical over-the-counter doses of ibuprofen are up to 1200mg per day and can be taken for up to three days. There is either no or minimal gastric damage at doses of less than 1600mg a day over three days. But people who take prescription
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