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Author: Admin | 2025-04-28
This receptor.Notably, 16% of the affected patients had taken fenfluramine or dexfenfluramine alone, without phentermine ( 4 ). As a result, fenfluramine and dexfenfluramine were withdrawn from the market, but phentermine remained available for pharmaceutical weight loss.Below is the official warning about phentermine and heart valve problems as written on the Adipex-P drug label ( 5 ):“Serious regurgitant cardiac valvular disease, primarily affecting the mitral, aortic and/or tricuspid valves, has been reported in otherwise healthy persons who had taken a combination of phentermine with fenfluramine or dexfenfluramine for weight loss. The possible role of phentermine in the etiology of these valvulopathies has not been established and their course in individuals after the drugs are stopped is not known. The possibility of an association between valvular heart disease and the use of phentermine alone cannot be ruled out; there have been rare cases of valvular heart disease in patients who reportedly have taken phentermine alone.”Phentermine and Pulmonary HypertensionPhentermine heart problems can be serious, or even fatalEight of the twenty-four women in the initial Mayo Clinic report also presented with primary pulmonary hypertension (PPH) after taking Phen-Fen ( 2 ).PPH is a rare condition in which the small blood vessels in the lungs narrow and force blood pressure to increase precipitously in the pulmonary artery: the vessel that carries blood from the heart to the lungs. It can be fatal if left untreated ( 6 ).A 2010 article suggested a link between phentermine monotherapy and the development of pulmonary hypertension, but these findings are not universally accepted ( 7 , 8 ).Below is the warning about primary pulmonary hypertension, as printed on the same Adipex-P drug label ( 5 ):“Primary Pulmonary Hypertension (PPH) – a rare, frequently fatal disease of the lungs – has been reported to occur in patients receiving a combination of phentermine with fenfluramine or dexfenfluramine. The possibility of an association between PPH and the use of phentermine alone cannot be ruled out; there have been rare cases of PPH in patients who reportedly have taken phentermine alone. The initial symptom of PPH is usually dyspnea. Other initial symptoms may include angina pectoris, syncope or lower extremity edema. Patients should be advised to report immediately any deterioration in exercise tolerance. Treatment should be discontinued in patients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or lower extremity edema, and patients should be evaluated for the possible presence of pulmonary hypertension.”Phentermine and Coronary VasospasmAlthough not listed on the medication’s official label, a 2019 case report from the Mayo Clinic suggests a potential link between phentermine use and increased risk of coronary vasospasm, especially in patients with a history of nicotine use or arthrosclerosis ( 9 , 10 ).Coronary vasospasm is the sudden narrowing of the blood vessels in the heart. It causes extreme chest pain that can feel like a heart attack and may lead to further complications if left untreated (including heart attack).Vasospasm is already a documented as potential reaction to other legal and illegal stimulant drugs
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