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Author: Admin | 2025-04-28
Not change the dosing times unless directed by your doctor. The dosage is based on your medical condition and response to treatment.Swallow this medication whole. Do not crush or chew the capsules. Doing so can release all of the drug at once and may increase your risk of side effects.Use this medication regularly to get the most benefit from it. Do not suddenly stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Tell your doctor if this medication stops working well (for example, you have worsening chest pain or it occurs more often).Nitroglycerin-vi descriptionsponsoredGlyceryl trinitrate, also known as Nitroglycerin-vi.Nitroglycerin-vi dosageAs noted above (CLINICAL PHARMACOLOGY), careful studies with other formulations of Nitroglycerin-vi have shown that maintenance of continuous 24- hour plasma levels of Nitroglycerin-vi results in tolerance (i.e., loss of clinical response). Every dosing regimen for Nitroglycerin-vi Slocaps® should provide a daily nitrate-free interval to avoid the development of this tolerance. The minimum necessary length of such an interval has not been defined, but studies with other Nitroglycerin-vi formulations have shown that 10-12 hours is sufficient. Large controlled studies with other formulations of Nitroglycerin-vi show that no dosing regimen with Nitroglycerin-vi Slocaps® should be expected to provide more than about 12 hours of continuous antianginal efficacy per day.The pharmacokinetics of Nitroglycerin-vi capsules, and the clinical effects of multiple-dose regimens, have not been well studied. In clinical trials, the initial regimen of Nitroglycerin-vi capsules has been 2.5 to 6.5 mg three to four times a day, with subsequent upward dose adjustment guided by symptoms and side effects. In one trial, 5 of the 18 subjects were titrated up to a dose of 26 mg four times a day.Nitroglycerin-vi interactionsSee also:What other drugs will affect Nitroglycerin-vi?sponsoredPDE5 inhibitors Phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.The time course of the interaction
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