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Author: Admin | 2025-04-28
Illicit drugs at the same time, they can develop multiple physical dependencies. If you have been combining or alternating your tramadol dose with another painkiller, like hydrocodone, your opioid dependence may be more severe. Increased Seizure Risk If you have become physically dependent on anti-anxiety medications (benzodiazepines) you are at risk of dangerous withdrawal complications, including seizures and delirium. Tramadol is also associated with seizure activity. Seizures can occur in people both with and without a history of seizures. People with a history of seizures or traumatic brain injury may be at increased risk during tramadol withdrawal. Tramadol has been shown to lower the seizure threshold, making seizures more likely to occur. Your risk is also increased if you take other medications that lower the seizure threshold, such as antipsychotics. Risk for Older Adults People over the age of 65 are also at increased risk of withdrawal complications. Older adults metabolize tramadol slower than younger people. This means that the drug has more powerful effects. In older adults, withdrawal may start later than normal and be more severe. Individual Factors While it is not common, some people do appear to be more sensitive to tramadol withdrawal than others.If you or someone you love is experiencing confusion, hallucinations, delusions, or severe agitation, you should bring them to the nearest emergency room. Serotonin Syndrome One other thing to be aware of is tramadol’s association with a dangerous condition called serotonin syndrome. Serotonin syndrome is unlikely to occur during withdrawal unless you relapse and take an unusually high dose. Serotonin syndrome typically occurs when you combine tramadol with one or more medications that affect your body’s serotonin levels, such as antidepressants, MAOIs, migraine medications, or illicit drugs. Symptoms of serotonin syndrome, which can be deadly without treatment, include: Dilated pupilsHeavy sweatingRapid heart rateTwitching
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